20th Anniversary Meeting of the FST

20th Anniversary Meeting of the Finnish Society of Toxicology:
"ENVIRONMENTAL TOXICOLOGY"
May 6-8, 1999
University of Turku, Yliopistonmäki, Life Science Building II, Lecture Hall XXI, Turku, Finland
PROGRAM DESCRIPTION
Thursday, May 6
THE ROLE OF CONJUGATION REACTIONS IN TOXICOLOGY: PROSPECTS FOR THE 21st CENTURY

A Symposium honouring Professor Osmo Hänninen's 60th Birthday

14:00	Opening of the Symposium. Prof. Harri Vainio, Stockholm, Sweden.
14:15	Xenobiotic Metabolism-State of the Art Thirty Years Ago. Prof. Sten Orrenius, Stockholm, Sweden.
15:00	Glucuronidation Reactions-from Simple Chemistry to Complex Genetic Traits. Prof. Brian Burchell, Dundee, Scotland.
15:45	From Glucuronide to Glutathione: about Friends and Enemies in Drug Conjugation. Prof. Gerald Mulder, Leiden, The Netherlands.
16:30	Significance of Conjugation Reactions in Drug Therapy. Prof. Marios Marselos, Ioannina University, Greece.
17:15	Zigs and Zags with a Common Theme: from Glucuronides through Vegan Diet to Antioxidants. Prof. Osmo Hänninen, Kuopio, Finland.
20:00	Symposium Dinner in "Old Town Hall" (In common with the meeting of the Horsecollar Knights and participants ofthe Finnish Society of Toxicology Meeting)

FRIDAY, MAY 7th

9:00-9:15 OPENING/WELCOME, Eino Hietanen, University of Turku, Finland

SESSION I: Environmental Toxicology: Endocrine Disruptors
Chairperson: Sten Orrenius, Stockholm, Sweden

9:15-9:45 Male reproductive system as a target of endocrine disruptors.
Jorma Toppari, University of Turku, Finland.

9:45-10:15 Pulp and paper mill effluents today: endocrine or population disrupters in fish?
Aimo Oikari, University of Jyväskylä, Finland.

10:15-10:45 Dietary phytoestrogens: mechanisms of action and possible impact on human health.
Sari Mäkelä, University of Turku, Finland.

10:45-11:15 COFFEE

11:15-11:45 Hormonal status in rat fetuses exposed to exohormones.
Jorma Paranko, University of Turku, Finland.

11:45-12:15 Role of apoptosis in cell killing.
Sten Orrenius, Stockholm, Sweden.

12:15-12:30 Spontaneous abortions in female personnel in biomedical research laboratoriesand birth weight among their children.
Helena Wennborg, Karolinska Institute, Stockholm, Sweden.

12:30-12:45 Polymorphism of CYP2A6 and new genotyping methods.
Harriet Gullstén, University of Oulu, Finland.

12:45-13:00 Reduced centrolobular defence capacity by glutathione peroxidase afterexposure to ethanol and low-carbohydrate diet.
Helmuth Sippel, University of Helsinki, Finland.

13:00-14:00 LUNCH

14:00-15:30 Annual Meeting of the Finnish Society of Toxicology

15:30-16:30 POSTER SESSION AND COFFEE

SESSION II: Mechanisms in Toxicology: Signal Transduction Chairperson:Kai Savolainen, Helsinki, Finland and Mika Scheinin, Turku, Finland

16:30-17:00 Regulation of mitogen-activated protein kinases by G-protein coupled receptors.
Christodoulos Flordellis, Greece.

17:00-17:30 GABAA receptor mechanisms at the molecular level: a target for compounds of toxicological importance.
Hartmut Lüddens, Germany.

17:30-18:00 Phosphorylation-mediated signalling in receptor-induced apoptosis.
John Eriksson, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland.

18:00-18:15 Expression of xenobiotic-metabolizing CYPs in human pulmonary tissues andA549 lung carcinoma cell line.
Janne Hukkanen, University of Oulu, Finland.

18:15-18:30 The glucuronidation assay of 1-hydroxypyrene is a UGT-method for low activity measurement in human extrahepatic tissues.
Eivor Elovaara, Finnish Institute of Occupational Health, Helsinki, Finland.

20:00 CONGRESS BANQUET AT NAANTALIN MERISALI RESTAURANT
Informal dress. Bus transport from Turku to Naantali:

19:30 - University of Turku
19:40 - Hotel Centro
19:45 - Hotel Rivoli
Return from Naantali to Turku at midnight (00:15).

SATURDAY, MAY 8th

SESSION III: Environmental Toxicology: In vitro toxicology
Chairpersons: Boris Isomaa, Turku, Finland and Pirjo Lindström-Seppä, Kuopio, Finland

9:30-10:00 Cellular mechanisms of metaltoxicity.
Mikko Nikinmaa, University of Turku, Finland:

10:00-10:30 In vitro methods in neurotoxicology.
Hanna Tähti, University of Tampere, Finland.

10:30-11:00 COFFEE

11:00-11:30 Mechanisms of action of drugs of abuse.
Esa Korpi, University of Turku, Finland.

11:30-11:45 Drug toxicity evaluation with in vitro techniques.
M. Marselos, University of Ioannina, Greece.

11:45-12:00 Construction of COMFA model for CYP2A6-inhibitory properties of 28compounds.
R. Juvonen, University of Kuopio, Finland.

12:00-12:15 Ability of dairy strains of lactic acid bacteria to bind aflatoxin M1 in a foodmodel.
Seppo Salminen, University of Turku, Finland.

12:15-12:30 Faecal recovery of aflatoxin B1 following bacterial treatment.
Hani El-Nezami, RMIT-University, Australia and University of Kuopio, Finland.

12:30-12:45 Cloning and characterization of tissue-specific expression of zebrafish (Danio rerio) heat shock factor 1 isoforms upon heat stress.
Christina Råbergh, University of Turku, Finland.

13:00 CLOSING OF THE MEETING: Tuula Heinonen, Chairperson of the Finnish Society of Toxicology

9:00-9:15	OPENING/WELCOME, Eino Hietanen, University of Turku, Finland
	SESSION I: Environmental Toxicology: Endocrine Disruptors Chairperson: Sten Orrenius, Stockholm, Sweden
9:15-9:45	Male reproductive system as a target of endocrine disruptors. Jorma Toppari, University of Turku, Finland.
9:45-10:15	Pulp and paper mill effluents today: endocrine or population disrupters in fish? Aimo Oikari, University of Jyväskylä, Finland.
10:15-10:45	Dietary phytoestrogens: mechanisms of action and possible impact on human health. Sari Mäkelä, University of Turku, Finland.
10:45-11:15	COFFEE
11:15-11:45	Hormonal status in rat fetuses exposed to exohormones. Jorma Paranko, University of Turku, Finland.
11:45-12:15	Role of apoptosis in cell killing. Sten Orrenius, Stockholm, Sweden.
12:15-12:30	Spontaneous abortions in female personnel in biomedical research laboratoriesand birth weight among their children. Helena Wennborg, Karolinska Institute, Stockholm, Sweden.
12:30-12:45	Polymorphism of CYP2A6 and new genotyping methods. Harriet Gullstén, University of Oulu, Finland.
12:45-13:00	Reduced centrolobular defence capacity by glutathione peroxidase afterexposure to ethanol and low-carbohydrate diet. Helmuth Sippel, University of Helsinki, Finland.
13:00-14:00	LUNCH
14:00-15:30	Annual Meeting of the Finnish Society of Toxicology
15:30-16:30	POSTER SESSION AND COFFEE
	SESSION II: Mechanisms in Toxicology: Signal Transduction Chairperson:Kai Savolainen, Helsinki, Finland and Mika Scheinin, Turku, Finland
16:30-17:00	Regulation of mitogen-activated protein kinases by G-protein coupled receptors. Christodoulos Flordellis, Greece.
17:00-17:30	GABAA receptor mechanisms at the molecular level: a target for compounds of toxicological importance. Hartmut Lüddens, Germany.
17:30-18:00	Phosphorylation-mediated signalling in receptor-induced apoptosis. John Eriksson, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Finland.
18:00-18:15	Expression of xenobiotic-metabolizing CYPs in human pulmonary tissues andA549 lung carcinoma cell line. Janne Hukkanen, University of Oulu, Finland.
18:15-18:30	The glucuronidation assay of 1-hydroxypyrene is a UGT-method for low activity measurement in human extrahepatic tissues. Eivor Elovaara, Finnish Institute of Occupational Health, Helsinki, Finland.
20:00	CONGRESS BANQUET AT NAANTALIN MERISALI RESTAURANT Informal dress. Bus transport from Turku to Naantali: 19:30 - University of Turku 19:40 - Hotel Centro 19:45 - Hotel Rivoli Return from Naantali to Turku at midnight (00:15).

	SESSION III: Environmental Toxicology: In vitro toxicology Chairpersons: Boris Isomaa, Turku, Finland and Pirjo Lindström-Seppä, Kuopio, Finland
9:30-10:00	Cellular mechanisms of metaltoxicity. Mikko Nikinmaa, University of Turku, Finland:
10:00-10:30	In vitro methods in neurotoxicology. Hanna Tähti, University of Tampere, Finland.
10:30-11:00	COFFEE
11:00-11:30	Mechanisms of action of drugs of abuse. Esa Korpi, University of Turku, Finland.
11:30-11:45	Drug toxicity evaluation with in vitro techniques. M. Marselos, University of Ioannina, Greece.
11:45-12:00	Construction of COMFA model for CYP2A6-inhibitory properties of 28compounds. R. Juvonen, University of Kuopio, Finland.
12:00-12:15	Ability of dairy strains of lactic acid bacteria to bind aflatoxin M1 in a foodmodel. Seppo Salminen, University of Turku, Finland.
12:15-12:30	Faecal recovery of aflatoxin B1 following bacterial treatment. Hani El-Nezami, RMIT-University, Australia and University of Kuopio, Finland.
12:30-12:45	Cloning and characterization of tissue-specific expression of zebrafish (Danio rerio) heat shock factor 1 isoforms upon heat stress. Christina Råbergh, University of Turku, Finland.
13:00	CLOSING OF THE MEETING: Tuula Heinonen, Chairperson of the Finnish Society of Toxicology